Technically...
Once you're east of Calabasas, you're in LA.
So, south of Rt 101, if you can afford it. I'm talking the LA Hills.
It is a bit cheaper north on Rt 101.
But, first you need a job.
Second, you should live near your job.
If you're that person looking for a job in the medical field.
They're building new hospital in Tarzana, near the library.
So, if you get an offer there, I would look....
North of 101 and west of Rt 405.
Parts of Reseda are seedy.
If you can't afford LA, try Santa Clarita or San Fernando.
Once you're out of the area, you'll be dealing with LA traffic.
So, Sherman Oaks and Studio City would be nice.
But you would need to travel Rt 101 and cross Rt 405.